Wireless transmission at 2.4 GHz covers a bigger region, whereas 5 GHz covers a smaller area but gives quicker rates. In simple terms is the interface mouse uses to transfer data. Microwaves, baby monitors, and garage door openers all use the 2.4 GHz frequency. If you have a lot of them or reside in an apartment or condo, the 2.4 GHz band is likely to be crowded, affecting the signal quality. 5GHz is the best option if you face any issues with the 2.4 GHz band. But mos wireless mouse only supports 2.4 GHz and some offers dual-band support. More about 2.4 GHz and 5GHz are explained here.